Last updated: 2025-03-13 429297 annotations 4738 curated publications
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Ontology term: abnormal chromatin silencing at centromere central core (FYPO:0000640)
Definition Parents
A transcription regulation phenotype observed in the vegetative growth phase of the life cycle in which chromatin silencing is abnormal at the centromere central core. Chromatin silencing is the observed effect of processes that repress transcription at the centromere central core, which is normally assembled into CENP-A-containing chromatin.
External links: BioPortal
Single locus phenotype annotations for FYPO:0000640 and its descendants
Cell
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+ abnormal chromatin silencing at centromere central core
alp5-1134(S402N aa) ,   scm3-106(L73F aa) ,   scm3-139(L56F aa) ,   scm3-15(S281L aa) ,   teb1-1(R184C aa)
+ decreased chromatin silencing at centromere central core
clr2Δ ,   cnp1-169(V52A aa) ,   cnp1-76(T74M aa) ,   cnp1-87(E92K aa) ,   cos1-17(V233A aa) ,   cos1-22(A574D aa) ,   cos1-38(G622E aa) ,   cos1-7(G242R aa) ,   cos1-86(Q765*) ,   dis3-54(P509L aa) ,   fft3Δ ,   fta2-292(F292L aa) ,   hst4Δ ,   mal2-1(E277K aa) ,   mis6-302(G135E aa) ,   sim3-143(G81E aa) ,   sim3-205(E207K aa) ,   mis15-68(W113R aa) ,   mis6-302(G135E aa)[Knockdown] ,   arp8Δ ,   clr1-5(unknown) ,   clr3-735(D232N aa) ,   clr3Δ ,   cnp1-1(L87Q aa) ,   dpb3Δ ,   dpb4Δ ,   hrp1Δ ,   iec1Δ ,   ies2Δ ,   ies6Δ ,   ino80-11(D1531V aa) ,   mcl1-101(P493S,L763F,A767V aa) ,   mcm2-2a(Y80A,Y89A aa) ,   pli1-C321S(aa) ,   pli1Δ ,   pob3Δ ,   pst1-1(W1305*) ,   swi7-1(G1116E aa) ,   swi7-H4(unknown)
+ increased chromatin silencing at centromere central core
alp13Δ ,   clr6-1(G269D aa) ,   cph1Δ ,   hat1Δ ,   clr6-1(G269D aa)
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