Last updated: 2024-12-30 427965 annotations 4705 curated publications
Ontology term: abnormal protein-containing complex assembly (FYPO:0000447)
Definition Parents
A cellular process phenotype observed in the vegetative growth phase of the life cycle in which any process of protein complex assembly at the cellular level is abnormal. is_a abnormal cellular component assembly during vegetative growth
is_a abnormal protein complex organization during vegetative growth
Single locus phenotype annotations for FYPO:0000447 and its descendants
Cell
Filters:
+ abnormal cytoplasmic interphase microtubule nucleation
rsp1Δ ,   mzt1+[Knockdown]
+ abnormal de novo SAGA complex assembly
git10-201(L338P aa) ,   tel2-AID[Knockdown]
+ abnormal gamma-tubulin complex assembly
gtb1-93(P302L aa)
+ abnormal kinetochore microtubule polymerization during mitotic metaphase chromosome recapture
klp5Δ
+ abnormal MCM complex assembly
mcb1-D2(2-53 Δaa) ,   mcb1-D22(2-53,E423G aa)
+ abnormal mitochondrial translation initiation complex assembly
mpa1Δ ,   ppr10Δ ,   ppr10ΔPPR(253-322 Δaa)[Knockdown]
+ abnormal mRNA cleavage and polyadenylation specificity factor complex assembly
seb1+[Knockdown]
+ abnormal protein oligomerization
ctp1-H11A,W12A,Y16A(aa) ,   cut7Δ431-1085(aa) ,   pcn1-6(G69D aa) ,   pcn1-L68S(aa)
+ abnormal ribosomal small subunit assembly
utp24+[Knockdown]
+ abnormal RITS complex assembly
sgf73Δ
+ abnormal spliceosomal complex assembly
gem8+[Knockdown] ,   tdSMN(Ub-DHFRts-smn1)
+ abnormal U6 snRNP assembly
bmc1Δ ,   pof8Δ
+ abolished astral microtubule nucleation during mitosis
pcp1-AID(pcp1::pcp1-XTEN16-3×sAID:kanMX6)[Knockdown]
+ abolished cytoplasmic interphase microtubule nucleation
mto2Δ
+ abolished cytoplasmic interphase microtubule nucleation from spindle pole body
mto1-9A1(DNLRKEVFG259AAAAAAAAA aa) ,   mto1-9A2(GLKLKCYFL267AAAAAAAAA aa) ,   mto1Δ
+ abolished cytoplasmic microtubule nucleation from iMTOC
mto1-334(523-537 Δaa) ,   mto1-9A2(GLKLKCYFL267AAAAAAAAA aa) ,   mto1-9A1(DNLRKEVFG259AAAAAAAAA aa) ,   mto1-9A2(GLKLKCYFL267AAAAAAAAA aa) ,   mto1Δ
+ abolished MBF complex assembly during mitotic G1 phase
cdc2-M26(P137S aa)
+ abolished MCM complex assembly
cdc19-D10(528-724 Δaa)[Knockdown] ,   cdc19-D4(45-126 Δaa)[Knockdown] ,   cdc19-D6(736-830 Δaa) ,   cdc19-D7(1-204 Δaa)[Knockdown] ,   cdc19-D8(528-613 Δaa)[Knockdown] ,   cdc19-D9(615-724 Δaa)[Knockdown] ,   cdc19-M1(C334S aa)[Knockdown] ,   cdc19-M2(C337S aa)[Knockdown] ,   cdc19-M3(C357S aa)[Knockdown] ,   cdc19-M4(C360S aa)[Knockdown] ,   cdc19-M5(G534R aa)[Knockdown] ,   cdc19-P1(P257L,T272I aa)[Knockdown] ,   cdc21-M68(unknown)
+ abolished microtubule polymerization
alp14-TOG1,2(W23A,R109A,W300A,K381A aa)
+ abolished nuclear RNA-directed RNA polymerase complex assembly
cid12Δ ,   hrr1Δ ,   rdp1Δ
+ abolished SMN complex assembly
gem8ΔN58(1-58 Δaa) ,   smn1-ΔYG(120-152 Δaa)
+ abolished U2-type prespliceosome assembly
prp11-AEAD(D575A aa) ,   prp11-DAAD(E576A aa) ,   prp11-GAT(K468A aa) ,   prp11-GKA(T469A aa) ,   prp11-SAA(T608A aa) ,   prp2-2(T259I aa) ,   prp2-3(unknown) ,   prp2-C387Y(aa) ,   snu2+[Knockdown]
+ abolished U2/U5/U6 snRNP complex assembly
prp2-2(T259I aa) ,   prp2-C387Y(aa)
+ decreased anaphase-promoting complex assembly
hcn1Δ
+ decreased CENP-A containing chromatin assembly
fft3Δ ,   hrp1Δ ,   iec1Δ ,   ies6Δ ,   mis14-271(L106P aa) ,   mis15-68(W113R aa) ,   mis16-53(unknown) ,   mis17-362(S353P aa) ,   mis18-262(G117D aa) ,   mis6-302(G135E aa) ,   scm3-106(L73F aa) ,   scm3-139(L56F aa) ,   scm3-15(S281L aa) ,   sim4-193(unknown) ,   ccp1+[Overexpression]
ams2::ura4[Null] affecting regional_centromere_inner_repeat_region
+ decreased eukaryotic translation initiation factor 2B complex assembly
gcn3-F253V(aa) ,   gcn3-N222Y(aa) ,   gcn3-V197F(aa)
+ decreased interphase microtubule nucleation
alp14-26(C450R aa) ,   mto1-9A2(GLKLKCYFL267AAAAAAAAA aa)
+ decreased MCM complex assembly
cdc19-M6(K540A aa)[Knockdown] ,   cdc19-M7(K540R aa)[Knockdown] ,   cdc19-M8(D598A aa)[Knockdown] ,   cdc19-P1(P257L,T272I aa) ,   mcm4-DA(D609A aa) ,   mcm4-KA(K551A aa)
+ decreased microtubule polymerization
alp14-26(C450R aa) ,   alp14Δ ,   klp6Δ ,   mal3-S147A,S151A(aa) ,   mal3-S147E,S151E(aa) ,   mal3-S147E(aa) ,   nda3-TB101(Y50S aa)
+ decreased mitochondrial respiratory chain complex assembly
mti2Δ
+ decreased mitochondrial respiratory chain complex III assembly
cbp3Δ ,   cbp6Δ ,   cob1Δ
+ decreased mitochondrial respiratory chain complex IV assembly
cob1Δ ,   shy1Δ
+ decreased mitotic microtubule nucleation
alp14-26(C450R aa) ,   alp16Δ ,   gfh1Δ ,   mod21Δ
+ decreased mitotic spindle microtubule nucleation from spindle pole body
pcp1-15(I172T,K543E,I624T,E732G,A1022V,I1153V,H1163R aa) ,   pcp1-18(L254S,L717P aa)
+ decreased Mre11 complex assembly
mre11-W248R(aa) ,   nbs1-K522A(aa)
+ decreased pre-replicative complex assembly
mcm6-S1(E824G,D825N aa)
+ decreased rate of cytoplasmic microtubule polymerization during mitotic interphase
rqc2Δ ,   tea2Δ
+ decreased rate of interpolar microtubule polymerization during mitotic anaphase B
mal3Δ ,   peg1+[Overexpression]
+ decreased rate of microtubule polymerization during vegetative growth
alp14Δ ,   atb2-983(V260I aa)
+ decreased SMN complex assembly
smn1-A134E(aa) ,   smn1-S130D(aa)
+ decreased spatial extent of CENP-A containing chromatin assembly
hrp1Δ ,   mcl1-101(P493S,L763F,A767V aa) ,   mis6-302(G135E aa) ,   swi7-H4(unknown)
+ decreased spatial extent of interphase microtubule polymerization
tea2-G364A(aa) ,   tea2-T225N(aa) ,   tea2Δ
+ decreased U2-type prespliceosome assembly
prp11+[Knockdown] ,   prp11-AALD(DP303AA aa) ,   prp11-D303A(aa) ,   prp11-DPAA(LD305AA aa) ,   prp11-L305A(aa) ,   prp11-ΔB(1-170 Δaa) ,   prp11-ΔC(1-271 Δaa) ,   prp11-ΔD(1-426 Δaa) ,   prp11-ΔE(171-1014 Δaa) ,   prp11-ΔF(1-170,427-1014 Δaa)
+ delayed onset of mitotic spindle microtubule nucleation from old spindle pole body
cut11-1(L521F aa) ,   cut12-1(R536*)
+ ectopic CENP-A containing chromatin assembly
ccp1Δ ,   cnp1+[Overexpression] ,   ccp1-4A(L10A,F17A,I24A,F32A aa) ,   ccp1Δ ,   pht1Δ
+ ectopic CENP-A containing chromatin assembly at pericentromeric heterochromatin
sfh1-13(E225D,K254E,P292Q aa) affected region regional_centromere_outer_repeat_region
snf21-36(V404A,E461K,S566L,I571V aa) affected region regional_centromere_outer_repeat_region
+ ectopic septin ring assembly during vegetative growth
spn2Δ ,   spn3Δ ,   spt20Δ
+ increased microtubule polymerization
gtb1-93(P302L aa) ,   klp5Δ ,   klp6Δ ,   mal3-Q89R(aa)[Overexpression]
+ increased protein oligomerization
rmt1Δ affecting pab2
+ increased rate of interpolar microtubule polymerization during mitotic anaphase B
ase1+[Knockdown] ,   peg1+[Knockdown]
+ increased rate of interpolar microtubule polymerization inside the mitotic nuclear membrane bridge
ase1Δ ,   les1Δ ,   nem1Δ
+ increased rate of pre-replicative complex assembly
hpz1Δ
+ increased spatial extent of CENP-A containing chromatin assembly
cut8Δ ,   rpt3-1(Q384*) ,   cdc20-P7(unknown)
cnp1+[Overexpression] affecting cnp1
+ monopolar mitotic spindle nucleated from old spindle pole body
cut11-1(L521F aa) ,   cut12-1(R536*) ,   pcp1-15(I172T,K543E,I624T,E732G,A1022V,I1153V,H1163R aa) ,   pcp1-18(L254S,L717P aa)
+ septin ring assembly during mitotic interphase
mid1-18(unknown)[Overexpression]
Multi-locus phenotype annotations for FYPO:0000447 and its descendants
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