Last updated: 2025-03-13 429297 annotations 4738 curated publications
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Ontology term: abnormal mitotic G2/M phase transition (FYPO:0000399)
Definition Parents
A cellular process phenotype in which the G2/M transition of the mitotic cell cycle is abnormal.
External links: BioPortal
Single locus phenotype annotations for FYPO:0000399 and its descendants
Cell
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Filters:
+ abnormal cytokinesis checkpoint
byr4+[Overexpression] ,   rad24Δ
+ abnormal mitotic cell cycle DNA replication checkpoint
cdc20-P287R(aa) ,   him1-Del6(1-176 Δaa) ,   him1-Δ154-194(aa) ,   him1-Δ154-222(aa) ,   him1-Δ177-222(aa) ,   lem2Δ ,   orp1-4(unknown) ,   trx1Δ
+ abnormal mitotic G2 DNA damage checkpoint
rad1::ura4
+ abolished cytokinesis checkpoint
cdc14-118(S213P aa)
+ abolished mitotic cell cycle DNA replication checkpoint
cdc18+[Knockdown]
+ abolished mitotic G2 DNA damage checkpoint
chk1-S345A(aa) ,   chk1Δ ,   rad3Δ ,   rfc2Δ ,   crb2Δ
+ abolished mitotic G2 DNA damage checkpoint during cellular response to ionizing radiation
cdc2-Y15F(aa) ,   cdc25+[Overexpression]
+ decreased duration of mitotic cell cycle DNA replication checkpoint
chk1-1(E92D aa) ,   rfc3-1(R216W aa)
+ decreased duration of mitotic G2 DNA damage checkpoint
crb2-K619M(aa) ,   crb2-S548A(aa)
+ decreased response to mitotic G2 DNA damage checkpoint signaling
rfc3-1(R216W aa) ,   tel2-C307Y(aa) ,   crb2Δ ,   set9Δ ,   spp1-14(unknown) ,   spp1-21(unknown) ,   spp1-4(unknown)
+ delayed onset of mitotic G2 DNA damage checkpoint
xlf1.AA(T180A,S192A aa)[Overexpression]
+ increased duration of mitotic cell cycle DNA replication checkpoint
cnd2-1(A114T aa) ,   mcm4Δ828-911(aa) ,   nap1Δ ,   rgf1Δ
+ increased duration of mitotic G2 DNA damage checkpoint during cellular response to ionizing radiation
ctp1Δ
+ inviable elongated cell with mitotic G2/M transition delay and cell cycle arrest in M phase
clp1+[Overexpression] ,   ubc11+[Knockdown]
+ mitotic G2/M phase transition delay
ago1-NT(427-834 Δaa)[Overexpression] ,   cdc10+[Overexpression] ,   cdc14+[Overexpression] ,   cdc15-140(unknown) ,   cdc18+[Overexpression] ,   cdc7-24(unknown) ,   cdk8-D158A(aa) ,   dnt1Δ ,   dsk1+[Overexpression] ,   fkh2-S2A(S322A,S375A aa) ,   fkh2Δ ,   hub1-4(T209A nt) ,   mcb1-S452P,S484P(aa) ,   mcb1-S465P(aa) ,   mcm4+[Overexpression] ,   mor2-786(A1673G nt) ,   mus7Δ ,   nap1Δ ,   nda1-KM376(unknown) ,   nda4-108(R50C aa) ,   orb6-25(unknown) ,   orc2+[Overexpression] ,   pcn1+[Overexpression] ,   pmo25-35(L79H aa) ,   ppk11Δ ,   prp4-as2(F238A aa) ,   psf1-HBD ,   psf2-HBD ,   puc1+[Overexpression] ,   pyp1-C470S(aa)[Overexpression] ,   sds21+[Overexpression] ,   sid2-250(E314K aa) ,   spg1-106(T97I aa) ,   tor1-L2045D(aa) ,   cdc2-T14S(aa)
+ premature mitotic G2/M phase transition
fkh2-S2E(S322E,S375E aa) ,   hsp9Δ ,   wee1-50(G850E aa) ,   cdc2-1w(G146D aa) ,   pom1Δ ,   wee1-50(G850E aa) ,   wis1-DD(S469D,T473D aa) ,   cdc13-HPM(M235A,L239A,W242A aa)
+ viable elongated vegetative cell, elongated upon mitotic entry
ase1Δ ,   blt1Δ ,   cdc13-117(C379Y aa) ,   cdc2-33(A177T aa) ,   cdc25-22(C532Y aa) ,   cdr1-82(unknown) ,   cdr1Δ ,   cdr2+[Overexpression] ,   cdr2-4D(S758D,S760D,S761D,S762D aa) ,   cdr2-67(unknown) ,   cdr2-96(unknown) ,   cdr2-97(unknown) ,   cdr2-D1(disruption) ,   cdr2-D2(cdr2::ura4) ,   cdr2-E177A(aa) ,   cdr2-E177A(aa)[Overexpression] ,   cdr2-K39R(aa) ,   cdr2-T166A(aa) ,   cdr2-T166E(aa) ,   cdr2Δ ,   cig2Δ ,   efm2+[Overexpression] ,   fin1-A5(Y84N aa) ,   fin1-as3(M82G,G168A aa) ,   fin1Δ ,   hst4Δ ,   kms2+[Knockdown] ,   lid2-j(unknown) ,   mcs4Δ ,   nif1+[Overexpression] ,   pom1+[Overexpression] ,   pom1-cdr2C-GFP(pom1-cdr2(252-352)-GFP) ,   pom1Δ305N(10-303 Δaa)[Overexpression] ,   pom1Δ305N-cdr2C-chimera(pom1delta(10-303)-cdr2(252-352)) ,   puc1-Δ88(1-88 Δaa)[Overexpression] ,   sid2-as4(M285A,T348A aa) ,   ssp1Δ ,   sty1-5CS(C13S,C35S,C153S,C158S,C242S aa) ,   sty1Δ ,   tor1Δ ,   wee1+[Overexpression] ,   wis1Δ ,   yox1Δ ,   cdc13-RLuc ,   pps1Δ ,   sal3-33(unknown) ,   sal3Δ ,   cdc25-11A1(S3A,S66A,S84A,T89A,T104A,S113A,S118A,S143A,S308A,T351A,T379A aa) ,   cdc25-11A2(S3A,S66A,T89A,T104A,S113A,S118A,S143A,S308A,S334A,T351A,T379A aa) ,   cdc25-11A3(S66A,S84A,T89A,T104A,S113A,S118A,S143A,S308A,S334A,T351A,T379A aa) ,   cdc25-13A(S3A,S66A,S84A,T89A,T104A,S113A,S118A,S143A,S308A,S332A,S334A,T351A,T379A aa) ,   cdc25-22(C532Y aa) ,   cdc25-3A-1(S66A,S143A,S332A aa) ,   cdc25-3A-2(T104A,S332A,T351A aa) ,   cdc25-5A-1(S66A,T104A,S143A,S332A,T351A aa) ,   cdc25-5A-2(S84A,S113A,S118A,S308A,S334A aa) ,   cdc25-7A(S66A,S84A,T104A,S118A,S143A,S332A,T351A aa) ,   cdc25-9A-b(S3A,S66A,S84A,T104A,S118A,S143A,S332A,S334A,T351A aa) ,   cdr1Δ ,   cdr2Δ ,   cpc2-R36D,K38E(aa) ,   cpc2Δ ,   ctp1Δ ,   klp9+[Overexpression] ,   ksg1-208(G159E aa) ,   nod1Δ ,   pom1+[Overexpression] ,   rga2Δ ,   saf5+[Overexpression] ,   sty1Δ ,   tea1Δ ,   cdc25-13A(S3A,S66A,S84A,T89A,T104A,S113A,S118A,S143A,S308A,S332A,S334A,T351A,T379A aa) ,   cpc2Δ ,   sin1Δ ,   sty1Δ ,   cdc25-13A(S3A,S66A,S84A,T89A,T104A,S113A,S118A,S143A,S308A,S332A,S334A,T351A,T379A aa)
cdr2-E177A(aa) affecting wee1
+ viable elongated vegetative cell, with progressive elongation
cdc13-c1(unknown) ,   prp2-2(T259I aa) ,   tpz1-L449A(aa) ,   trt1Δ
Multi-locus phenotype annotations for FYPO:0000399 and its descendants
Cell
Show details ...
Filters:
+ abnormal mitotic cell cycle DNA replication checkpoint
cdc20-P7(unknown) cid12Δ ,   cdc21-M68(unknown) orp1-4(unknown) ,   cdc27-P11(G57E aa) cid12Δ ,   trx1Δ txl1Δ
+ abolished mitotic cell cycle DNA replication checkpoint
cdc18-K46(unknown) orp1-4(unknown) ,   cds1-T11A(aa) chk1Δ ,   cds1-T8A,T11A(aa) chk1Δ ,   cdc18+[Overexpression] rad3-ts(unknown)
+ abolished mitotic G2 DNA damage checkpoint
cdc2-3w(C67Y aa) cdc25Δ ,   cdc2-3w(C67Y aa) cdc25Δ chk1+[Overexpression] ,   chk1Δ mik1Δ wee1-50(G850E aa)
+ decreased duration of mitotic cell cycle DNA replication checkpoint
cdc18-K46(unknown) cds1+[Overexpression] orp1-4(unknown) ,   cdc18-K46(unknown) orp1-4(unknown)
+ decreased duration of mitotic G2 DNA damage checkpoint
crb2-K619M(aa) crb2-S548A(aa) ,   hta1-S129A(aa) hta2-S128A(aa)
+ decreased duration of mitotic G2 DNA damage checkpoint during cellular response to ionizing radiation
mik1Δ wee1-50(G850E aa)
+ decreased response to mitotic G2 DNA damage checkpoint signaling
crb2-T215A(aa) set9Δ
+ increased duration of mitotic G2 DNA damage checkpoint during cellular response to ionizing radiation
ctp1Δ rad3Δ
+ increased mitotic G2/M phase transition
cdc18-C(150-577),T374A(1-149,T374A aa)[Overexpression] hus1-14(unknown) ,   cdc18-C(150-577),T374A(1-149,T374A aa)[Overexpression] rad17-h21(unknown) ,   cdc18-C(150-577),T374A(1-149,T374A aa)[Overexpression] rad3-136(unknown) ,   cdc18-C(150-577),T374A(1-149,T374A aa)[Overexpression] rad9-192(unknown) ,   cdc18-C(150-577)(1-149 Δaa)[Overexpression] hus1-14(unknown) ,   cdc18-C(150-577)(1-149 Δaa)[Overexpression] rad17-h21(unknown) ,   cdc18-C(150-577)(1-149 Δaa)[Overexpression] rad3-136(unknown) ,   cdc18-C(150-577)(1-149 Δaa)[Overexpression] rad9-192(unknown) ,   cdc18-C(150-577),T374A(1-149,T374A aa)[Overexpression] cut5-580(unknown) ,   cdc18-C(150-577)(1-149 Δaa)[Overexpression] cut5-580(unknown)
+ inviable small vegetative cell with premature mitotic G2/M phase transition
mik1Δ wee1-50(G850E aa)
+ mitotic G2/M phase transition delay
atf1Δ cdc25-22(C532Y aa) ,   cdc2-3w(C67Y aa) pcn1+[Overexpression] ,   cdc7-24(unknown) mor2-786(A1673G nt) ,   exo1+[Knockdown] rad2Δ ,   mor2-786(A1673G nt) orb6-25(unknown) ,   rap1Δ sds21+[Overexpression]
+ premature mitotic G2/M phase transition
atf1+[Overexpression] wee1-50(G850E aa) ,   cdc1-7(unknown) wee1-6(unknown) ,   cdc1-P13(D389G aa) wee1-6(unknown) ,   cdc13-563(G282D aa) mik1Δ wee1-50(G850E aa) ,   cdc2-3w(C67Y aa) nif1Δ pom1-as1(T778G aa) ,   cdc2-1w(G146D aa) cpc2Δ ,   cpc2Δ wee1-50(G850E aa)
+ premature mitotic G2/M phase transition during cellular response to osmotic stress
atf1Δ srk1Δ
+ viable elongated vegetative cell, elongated upon mitotic entry
cdc2-33(A177T aa) cdr1-76(unknown) ,   cdc2-33(A177T aa) cdr2-97(unknown) ,   cdc2-3w(C67Y aa) cdc25Δ tor1Δ ,   cdc25-22(C532Y aa) cdr1-76(unknown) ,   cdc25-22(C532Y aa) cdr2-97(unknown) ,   cdr1Δ mid1-9A(S110A,S127A,S218A,S227A,S329A,S432A,S452A,S464A,S531A aa) ,   cdr2Δ mid1-9A(S110A,S127A,S218A,S227A,S329A,S432A,S452A,S464A,S531A aa) ,   cut14+[Overexpression] cut3+[Overexpression] ,   sty1-tpx1-C48S(Sty1-Tpx1-C48S@sty1) wis1-AA(S469A,T473A aa) ,   sty1-tpx1(Sty1-Tpx1@sty1) wis1-AA(S469A,T473A aa) ,   cdc2-3w(C67Y aa) cdc25Δ chk1+[Overexpression] ,   cdc2-3w(C67Y aa) chk1+[Overexpression] ,   cdr1-34(unknown) spo12+[Overexpression] ,   cdr1-34(unknown) wis1+[Overexpression] ,   cdr1-34(unknown) wis2+[Overexpression] ,   cdr1-34(unknown) wis4+[Overexpression] ,   cdr2-69(unknown) spo12+[Overexpression] ,   cdr2-69(unknown) wis1+[Overexpression] ,   cdr2-69(unknown) wis2+[Overexpression] ,   cdr2-69(unknown) wis4+[Overexpression] ,   hht1Δ hht2-K56Q(K57Q aa) hht3Δ ,   hht1Δ hht2-K56R(K57R aa) hht3Δ ,   arf6Δ cdc25-22(C532Y aa) ,   cdc2-3w(C67Y aa) cdc25Δ ,   cdc2-3w(C67Y aa) cdc25Δ cpc2Δ ,   cdc25-22(C532Y aa) cpc2Δ ,   cdc25-22(C532Y aa) mpn1Δ ,   cdc25-22(C532Y aa) pom1+[Overexpression] ,   cdc25-22(C532Y aa) pom1Δ ,   cdc25-22(C532Y aa) syt22Δ ,   cdc25-22(C532Y aa) tea1Δ ,   cdr1Δ cdr2Δ pom1Δ ,   cdr1Δ pom1+[Overexpression] ,   cdr1Δ pom1Δ ,   cdr2Δ cpc2Δ ,   cdr2Δ pom1+[Overexpression] ,   cdr2Δ pom1Δ ,   cdr2Δ rga2Δ ,   cdr2Δ tea1Δ ,   cpc2Δ sty1Δ ,   ksg1-208(G159E aa) pdk1Δ ,   rnh1Δ rnh201Δ ,   sty1Δ tor1Δ ,   cpc2Δ pck2Δ ,   cpc2Δ pmk1Δ ,   cdc13-117(C379Y aa) cdc25-13A(S3A,S66A,S84A,T89A,T104A,S113A,S118A,S143A,S308A,S332A,S334A,T351A,T379A aa) ,   cdc2-33(A177T aa) cdc25-13A(S3A,S66A,S84A,T89A,T104A,S113A,S118A,S143A,S308A,S332A,S334A,T351A,T379A aa) ,   cdc2-L7(P208S aa) cdc25-13A(S3A,S66A,S84A,T89A,T104A,S113A,S118A,S143A,S308A,S332A,S334A,T351A,T379A aa) ,   cdc25-13A(S3A,S66A,S84A,T89A,T104A,S113A,S118A,S143A,S308A,S332A,S334A,T351A,T379A aa) cdr1Δ ,   cdc25-13A(S3A,S66A,S84A,T89A,T104A,S113A,S118A,S143A,S308A,S332A,S334A,T351A,T379A aa) cdr2Δ ,   cdc25-13A(S3A,S66A,S84A,T89A,T104A,S113A,S118A,S143A,S308A,S332A,S334A,T351A,T379A aa) clp1Δ ,   cdc25-13A(S3A,S66A,S84A,T89A,T104A,S113A,S118A,S143A,S308A,S332A,S334A,T351A,T379A aa) wee1Δ
+ viable elongated vegetative cell, with progressive elongation
cds1Δ trt1Δ ,   ppr10Δ sty1Δ
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